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signalchemlifesciences——激酶研究
SignalChem Lifesciences Corporation (“SLC”)公司總部位于加拿大不列顛哥倫比亞，是激酶研究領(lǐng)域的企業(yè)，其兩大核心產(chǎn)品系列為生物試劑及研究服務(wù)與藥物研發(fā)服務(wù)部。生物試劑及研究服務(wù)（SignalChem Pharmaceuticals Inc）始于2004年，致力于研發(fā)和生產(chǎn)生物醫(yī)藥研究和藥物研發(fā)領(lǐng)域的激酶產(chǎn)品，目前擁有的激酶/表觀遺傳相關(guān)酶類及其檢測試劑產(chǎn)品超過2000種，覆蓋幾乎所有激酶靶點以及表觀遺傳研究相關(guān)酶類，以及多種信號蛋白相關(guān)產(chǎn)品。同時，為輔助檢測激酶及臨床疾病和個體化治療，SignalChem還在生物標(biāo)志物及診斷試劑盒領(lǐng)域有著數(shù)十年的積淀，擁有強大和豐富的相關(guān)產(chǎn)品。藥物研發(fā)服務(wù)部致力于尋找新的小分子激酶抑制劑，并用于臨床治療。憑借公司豐富的激酶特異性小分子復(fù)合物資源庫，以及公司在激酶研究領(lǐng)域強大研究團(tuán)隊和豐富研究經(jīng)驗，SLC在以激酶及其通路為靶點的藥物設(shè)計、研發(fā)和生產(chǎn)具有*優(yōu)勢，目前公司已擁有大量的以激酶為靶點的小分子抑制劑產(chǎn)品，可用于研究各種腫瘤等疾病。蛋白激酶是聯(lián)結(jié)所有細(xì)胞活動的中樞，通過過表達(dá)/過度激活及突變蛋白激酶可導(dǎo)致機體功能異常進(jìn)而引發(fā)疾病，因此靶向激酶的藥物有著重要的臨床應(yīng)用價值。蛋白激酶家族是僅次于G蛋白偶聯(lián)受體家族的第二大藥物靶點，目前已發(fā)現(xiàn)約518種野生型的激酶族以及與其相關(guān)的臨床突變案例，有超過30種FDA認(rèn)證的激酶抑制劑。憑借著多年來以激酶為核心的細(xì)胞信號相關(guān)產(chǎn)品研發(fā)積累，以及為科研院所及制藥企業(yè)科研服務(wù)經(jīng)驗，SignalChem在抑制激酶活性的藥物領(lǐng)域處于水平，公司不僅擁有zui大的且不斷成長的活性激酶及突變激酶產(chǎn)品線，以及可在多個檢測平臺實施的激酶活性檢測試劑盒，而且不斷與多個大型制藥企業(yè)和研究院所廣泛合作，公司的主要產(chǎn)及服務(wù)包括：
1、憑借公司強大的科研力量和經(jīng)驗，SignalChem推出的“Kinome Search Engine”激酶篩選系統(tǒng)，可對每一個激酶族中的單個激酶做出檢測，從而輔助和加快激酶藥物的研發(fā)。
2、“Kinome Search Engine”激酶篩選系統(tǒng)不僅可輔助設(shè)計激酶藥物，還可進(jìn)一步研究人類激酶族的功能和機制，加深對未知激酶的認(rèn)識，尋找更多的藥物靶點，（目前認(rèn)證的藥物僅僅有少于5%是以已知的激酶通路為靶點，因此激酶通路作為藥物靶點有著巨大的潛力和價值）。
3、SignalChem公司擁有激酶相關(guān)臨床突變數(shù)據(jù)庫，在研究疾病復(fù)發(fā)和抗藥領(lǐng)域的核心問題時有著的優(yōu)勢，可以更為有效地協(xié)助制藥企業(yè)進(jìn)行藥物研發(fā)。
除了藥物研發(fā)方面的優(yōu)勢，SignalChem還在生物標(biāo)志物及診斷試劑盒領(lǐng)域有著數(shù)十年的積淀，擁有強大和豐富的相關(guān)產(chǎn)品。
目前SLC公司的產(chǎn)品覆蓋了幾乎所有細(xì)胞內(nèi)激酶相關(guān)通路，包括AKT/PKB通路、ERK/MAPK通路、JAK/STAT通路、JNK/SAPK通路、NfkB通路、p38通路、PKA/PKC通路、WNT信號通路等，適用于血管再生、凋亡和自噬、腫瘤、心血管疾病、細(xì)胞周期、細(xì)胞應(yīng)激、胞內(nèi)酪氨酸激酶、炎癥、浸潤和轉(zhuǎn)移、脂質(zhì)激酶、代謝性疾病、神經(jīng)生物學(xué)、磷酸酶/磷酸二酯酶、受體酪氨酸激酶、Ser/Thr激酶等研究領(lǐng)域。主要產(chǎn)品有：
一、蛋白酶類產(chǎn)品系列
1、高活性乙酰轉(zhuǎn)移酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
KAT2A (GCN5), Active | K311-381G | Human | GST tag | Sf9 insect cells | 323-end | NM_021078 |
KAT2B (PCAF), Active | K311-381BG | Human | GST tag | Sf9 insect cells | 431-end | NM_003884 |
KAT3A (CREBBP), Active | K312-381G | Human | GST tag | Sf9 insect cells | 1319-1710 | NM_004380 |
KAT5 (TIP60), Active | K314-380G | Human | GST tag | Sf9 insect cells | Full Length | NM_006388 |
KAT6B (MYST4), Active | K315-381BG | Human | GST tag | Sf9 insect cells | 431-end | NM_012330 |
KAT7 (MYST2), Active | K316-380G | Human | GST tag | Sf9 insect cells | Full Length | NM_007067 |
2、高活性精氨酸脫亞氨酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
PAD Cocktail, Active | P312-37C | - | - | - | Full Length | - |
3、高活性GTP/ATP酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
CDC42, Active | C108-310GH | Human | GST/His | E.coli | Full length | NM_001791 |
GNAI1, Active | G121-310G | Human | GST tag | E.coli | 2-end | NM_002069 |
GNAI2, Active | G122-310G | Human | GST tag | E.coli | 2-end | NM_002070 |
GNAI3, Active | G123-310G | Human | GST tag | E.coli | 2-end | NM_006496 |
GNAS, Active | G127-310G | Human | GST tag | E.coli | Full length | NM_000516 |
HRAS1 (Mature form), Active | R105-310H | Human | His tag | E.coli | 2-186 | NM_005343 |
KRAS (Mature form), Active | R106-310H | Human | His tag | E.coli | 2-186 | NM_033360 |
NRAS (Mature form), Active | R107-310H | Human | His tag | E.coli | 2-186 | NM_002524 |
RAC1, Active | R103-310G | Human | GST tag | E.coli | Full length | NM_006908 |
RAC2, Active | R104-310H | Human | His tag | E.coli | Full length | NM_002872 |
RAC3, Active | R102-310H | Human | His tag | E.coli | Full length | NM_005052 |
RhoA (Mature form), Active | R144-310H | Human | His tag | E.coli | 1-190 | NM_001664 |
RhoC (Mature form), Active | R144-310CH | Human | His tag | E.coli | 1-190 | NM_175744 |
RhoD (Mature form), Active | R144-310DH | Human | His tag | E.coli | 1-207 | BC001338 |
VCP, Active | V116-310G | Human | GST tag | Sf9 insect cells | Full length | NM_007126 |
4、高活性組蛋白去乙酰化酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
HDAC1, Active | H83-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_004964 |
HDAC10, Active | H92-31G | Human | GST tag | Sf9 insect cells | 1-482 | NM_032019 |
HDAC11, Active | H93-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_024827 |
HDAC2, Active | H84-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_001527 |
HDAC3, Active | H85-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_003883 |
HDAC3/NCOR2, Active | H85-38G | Human | GST tags | Sf9 insect cells | HDAC3 (full-length)/ NCOR2 (237-489) | NM_003883 |
HDAC4, Active | H86-31G | Human | GST tag | Sf9 insect cells | 612-end | NM_006037 |
HDAC5, Active | H87-31G | Mouse | GST tag | Sf9 insect cells | 617-end | BC060609 |
HDAC6, Active | H88-30G | Human | GST tag | Sf9 insect cells | Full Length | BC069243 |
HDAC7, Active | H89-31G | Human | GST tag | Sf9 insect cells | 501-end | NM_015401 |
HDAC8, Active | H90-30H | Human | His tag | Sf9 insect cells | Full Length | BC050433 |
5、活性突變激酶（共計253種）
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
ABL1 Mutant (E255K), Active | A03-12BG | Human | GST tag | Sf9 insect cells | 27-end (E255K) | NM_005157 |
ABL1 Mutant (E255V), Active | A03-12HH | Human | His tag | Sf9 insect cells | 27-end (E255V) | NM_005157 |
ABL1 Mutant (F317I), Active | A03-12JG | Human | GST tag | Sf9 insect cells | 27-end (F317I) | NM_005157 |
ABL1 Mutant (F317L), Active | A03-12IG | Human | GST tag | Sf9 insect cells | 27-end (F317L) | NM_005157 |
ABL1 Mutant (G250E), Active | A03-12CG | Human | GST tag | Sf9 insect cells | 27-end (G250E) | NM_005157 |
ABL1 Mutant (H396P), Active | A03-12LG | Human | GST tag | Sf9 insect cells | 27-end (H396P) | NM_005157 |
ABL1 Mutant (M351T), Active | A03-12KG | Human | GST tag | Sf9 insect cells | 27-end (M351T) | NM_005157 |
ABL1 Mutant (Q252H), Active | A03-12FG | Human | GST tag | Sf9 insect cells | 27-end (Q252H) | NM_005157 |
ABL1 Mutant (T315I), Active | A03-12DG | Human | GST tag | Sf9 insect cells | 27-end (T315I) | NM_005157 |
ABL1 Mutant (V299L), Active | A03-12MG | Human | GST tag | Sf9 insect cells | 27-end (V299L) | NM_005157 |
ABL1 Mutant (Y253F), Active | A03-12EG | Human | GST tag | Sf9 insect cells | 27-end (Y253F) | NM_005157 |
ABL1 Mutant (Y253H), Active | A03-12GH | Human | His tag | Sf9 insect cells | 27-end (Y253H) | NM_005157 |
AKT1 Mutant (E17K), Active | A16-12G | Human | GST tag | Sf9 insect cells | Full length (E17K) | NM_005163 |
AKT2 Mutant (E17K), Active | A17-12G | Human | GST tag | Sf9 insect cells | Full length (E17K) | NM_001626 |
AKT2 Mutant (R274H), Active | A17-12BG | Human | GST tag | Sf9 insect cells | Full length (R274H) | NM_001626 |
AKT3 Mutant (E17K), Active | A18-12G | Human | GST tag | Sf9 insect cells | Full Length (E17K) | NM_005465 |
AKT3 Mutant (G171R), Active | A18-12BG | Human | GST tag | Sf9 insect cells | Full length (G171R) | NM_005465 |
ALK Mutant (C1156Y), Active | A19-12DG | Human | GST tag | Sf9 insect cells | 1060-end (C1156Y) | NM_004304 |
ALK Mutant (F1174L), Active | A19-12EG | Human | GST tag | Sf9 insect cells | 1060-end (F1174L) | NM_004304 |
ALK Mutant (F1174S), Active | A19-12FG | Human | GST tag | Sf9 insect cells | 1060-end (F1174S) | NM_004304 |
ALK Mutant (G1202R), Active | A19-12HG | Human | GST tag | Sf9 insect cells | 1060-end (G1202R) | NM_004304 |
ALK Mutant (G1269A), Active | A19-12JG | Human | GST tag | Sf9 insect cells | 1060-end (G1269A) | NM_004304 |
ALK Mutant (G1269S), Active | A19-12KG | Human | GST tag | Sf9 insect cells | 1060-end (G1269S) | NM_004304 |
ALK Mutant (L1152R), Active | A19-12CG | Human | GST tag | Sf9 insect cells | 1060-end (L1152R) | NM_004304 |
ALK Mutant (L1196M), Active | A19-12GG | Human | GST tag | Sf9 insect cells | 1060-end (L1196M) | NM_004304 |
ALK Mutant (R1275Q), Active | A19-12LG | Human | GST tag | Sf9 insect cells | 1060-end (R1275Q) | NM_004304 |
ALK Mutant (S1206R), Active | A19-12IG | Human | GST tag | Sf9 insect cells | 1060-end (S1206R) | NM_004304 |
ALK Mutant (T1151M), Active | A19-12BG | Human | GST tag | Sf9 insect cells | 1060-end (T1151M) | NM_004304 |
ALK Mutant (T1151_L1152insT), Active | A19-12G | Human | GST tag | Sf9 insect cells | 1060-end (T1151_L1152insT) | NM_004304 |
ALK2 Mutant (PF197_198L), Active | A06-12FG | Human | GST tag | Sf9 insect cells | 147-end (PF197_198L) | NM_001105 |
ALK2 Mutant (Q207D), Active | A06-13CG | Human | GST tag | Sf9 insect cells | 147-end (Q207D) | NM_001105 |
ALK2 Mutant (Q207E), Active | A06-13DG | Human | GST tag | Sf9 insect cells | 147-end (Q207E) | NM_001105 |
ALK2 Mutant (R206H), Active | A06-12BG | Human | GST tag | Sf9 insect cells | 147-end (R206H) | NM_001105 |
ALK3 Mutant (Q233D), Active | B04-12BG | Human | GST tag | Sf9 insect cells | 187-end (Q233D) | NM_004329 |
ALK3 Mutant (R486Q), Active | B04-12CG | Human | GST tag | Sf9 insect cells | 187-end (R486Q) | NM_004329 |
AXL Mutant (R499C), Active | A34-12BG | Human | GST tag | Sf9 insect cells | 473-end (R499C) | NM_021913 |
BCR-RET Mutant, Active | R02-19EG | Human | GST tag | Sf9 insect cells | 1-426 (BCR) - 713-end (RET) | BC066122 |
BRAF Mutant (d485-489 P490Y), Active | B08-12IG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (d485-489 P490Y) | NM_004333 |
BRAF Mutant (G464V), Active | B08-12JG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (G464V) | NM_004333 |
BRAF Mutant (G469A), Active | B08-12FG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (G469A) | NM_004333 |
BRAF Mutant (K601E), Active | B08-12BG | Human | GST tag | Sf9 insect cells | 416-end (K601E) | NM_004333 |
BRAF Mutant (L597V), Active | B08-12HG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (L597V) | NM_004333 |
BRAF Mutant (R506_K507insVLR), Active | B08-13CG | Human | GST tag | Sf9 insect cells | 381-end or exon 9-18 (R506_K507insVLR) | NM_004333 |
6、活性激酶
該產(chǎn)品系列共包括445種激酶產(chǎn)品，下表僅列部分.
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
ABL1, Active | A03-11H | Mouse | His tag | Sf9 insect cells | 27-end | NM_009594 |
ABL1, Active | A03-18H | Human | His tag | Sf9 insect cells | 27-end | NM_005157 |
ABL2, Active | A04-11H | Human | His tag | Sf9 insect cells | 38-end | NM_005158 |
ACK, Active | A05-11G | Human | GST tag | Sf9 insect cells | 110-476 | NM_005781 |
AKT1, Active | A16-10G | Human | GST tag | Sf9 insect cells | Full Length | NM_005163 |
AKT2, Active | A17-10H | Human | His tag | Sf9 insect cells | Full Length | NM_001626 |
AKT2, Active | A17-10G | Human | GST tag | Sf9 insect cells | Full Length | NM_001626 |
AKT3, Active | A18-10G | Human | GST tag | Sf9 insect cells | Full Length | NM_005465 |
7、高活脂質(zhì)激酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
DGKA, Active | D21-10G | Human | GST tag | Sf9 insect cells | Full length | NM_001345 |
PI3K (p110 alpha (E545K)/p85 alpha), Active | P27-152H | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha (N345K(/p85 alpha), Active | P27-122CH | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha(E542K)/p85 alpha, Active | P27-122DH | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p55 gamma), Active | P27-102CH | Human | His tag | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p85 alpha), Active | P27-102G | Human | GST tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p85 alpha), Active | P27-102H | Human | His tags | Sf9 insect cells | Full length | NM_006218 |
PI3K (p110 alpha/p85 alpha), Active | P27-182H | Mouse | His tags | Sf9 insect cells | Full length | NM_008839 |
PI3K (p110 beta/p85 alpha), Active | P28-102H | Human | His tags | Sf9 insect cells | Full length | NM_006219 |
PI3K (p110 beta/p85 beta), Active | P28-102BH | Human | His tags | Sf9 insect cells | Full length | NM_006219 |
PI3K (p110 delta/p85 alpha), Active | P30-102H | Human | His tags | Sf9 insect cells | Full length | NM_005026 |
PI3K (p120 gamma), Active | P29-102H | Human | His tag | Sf9 insect cells | Full length | NM_002649 |
PI4K2A, Active | P21-102G | Human | GST tag | Sf9 insect cells | Full length | NM_018425 |
PI4K2B, Active | P22-102G | Human | GST tag | Sf9 insect cells | Full length | NM_018323 |
PI4KA, Active | P31-102G | Human | GST tag | Sf9 insect cells | Full length | NM_002650 |
PI4KB, Active | P32-102G | Human | GST tag | Sf9 insect cells | Full length | BC000029 |
PIK3C2A, Active | P23-112G | Human | GST tag | Sf9 insect cells | 299-end | NM_002645 |
PIK3C2B, Active | P24-112BG | Human | GST tag | Sf9 insect cells | 850-end | BC144342 |
8、高活性甲基轉(zhuǎn)移酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
COMT, Active | C339-381G | Human | GST tag | Sf9 insect cells | 27-271 | NM_000754 |
DNMT3A, Active | D353-380G | Human | GST tag | Sf9 insect cells | Full Length | BC043617 |
DNMT3B, Active | D353-380BG | Human | GST tag | Sf9 insect cells | Full Length | BC111933 |
DNMT3L, Active | D353-380CG | Human | GST tag | Sf9 insect cells | Full Length | BC002560 |
DOT1L (KMT4), Active | D344-381G | Human | GST tag | Sf9 insect cells | 1-435 | NM_032482 |
EHMT1 (KMT1D), Active | E317-381G | Human | GST tag | Sf9 insect cells | 895-end | NM_024757 |
EHMT2, Active | E318-381G | Human | GST tag | Sf9 insect cells | 807-end | NM_006709 |
LCMT1, Active | L321-380G | Human | GST tag | Sf9 insect cells | Full length | NM_016309 |
MLL1 (KMT2A), Active | M341-381G | Human | GST tag | Sf9 insect cells | 3738-end | NM_005933 |
MLL2 (KMT2D), Active | M342-381G | Human | GST tag | Sf9 insect cells | 5317-end | NM_003482 |
MLL3 (KMT2C), Active | M343-381G | Human | GST tag | Sf9 insect cells | 4689-end | NM_170606 |
9、高活性磷酸酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
CDC2, Active | C04-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_001789 |
CDC25B, Active | C04-20BG | Human | GST tag | Sf9 insect cells | Full Length | NM_021873 |
CDC25C, Active | C04-20CG | Human | GST tag | Sf9 insect cells | Full Length | BC019089 |
DUSP22 (MKPX), Active | D22-20G | Human | GST tag | E.coli | Full Length | NM_020185 |
PP1A, Active | P13-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_002708 |
PP1B, Active | P14-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_002709 |
PP2A alpha/PPP2R1A Complex, Active | P16-20BH | Human | His tags | Sf9 insect cells | Full length | NM_002715 |
PP2Aalpha, Active | P16-20G | Human | GST tag | Sf9 insect cells | Full Length | NM_002715 |
10、高活性磷酸二酯酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 | 基因號 |
PDE10A, Active | P98-31G | Human | GST tag | Sf9 insect cells | 71-end | NM_006661 |
PDE1A, Active | P89-30H | Human | His tag | Sf9 insect cells | Full Length | NM_005019 |
PDE1B, Active | P89-30BG | Human | GST tag | Sf9 insect cells | Full Length | NM_000924 |
PDE1C, Active | P89-30CG | Human | GST tag | Sf9 insect cells | Full Length | NM_005020 |
PDE2A, Active | P90-30G | Human | GST tag | Sf9 insect cells | Full Length | NM_002599 |
PDE3A, Active | P91-31G | Human | GST tag | Sf9 insect cells | 669-end | NM_000921 |
PDE3B, Active | P91-31BG | Human | GST tag | Sf9 insect cells | 654-end | NM_000922 |
PDE4A, Active | P92-31G | Human | GST tag | Sf9 insect cells | 332-end | NM_001111307 |
PDE4B, Active | P92-31BG | Human | GST tag | Sf9 insect cells | 305-end | NM_002600 |
PDE4C, Active | P92-31CG | Human | GST tag | Sf9 insect cells | 287-end | NM_000923 |
11、高活性蛋白酶
品名 | 貨號 | 種屬 | 標(biāo)記類型 | 表達(dá)系統(tǒng) | 氨基序列 |
CPB (carboxypeptidase B), Active | C560-31N | Rat | tag-free | Yeast cells | 109-end |
EK (enterokinase), Active | E535-31H | Swine | His tag | Yeast cells | 800-end |
Immobilized Lys-c, Agarose | L585-31AN | Bacteria | tag-free | E.coli | 206-473 aa |
Immobilized Lys-c, Silica | L585-31SN | Bacteria | tag-free | E.coli | 206-473 aa |
Immobilized Thrombin, Agarose | T565-31AN | Human | Native |
|
|
Immobilized Trypsin, Agarose | T575-31AN | Swine | tag-free | Yeast cells | 10-end |
Immobilized Trypsin, Silica | T575-31SN | Swine | tag-free | Yeast cells | 10-end |
KEX2 Protease, Active | K525-31N | Yeast | tag-free | Yeast cells | 110-660 aa |
Lys-c (lysyl-endopeptidase), Active | L585-31N | Bacteria | tag-free | E.coli | 206-473 aa |
二、抗體產(chǎn)品系列
1、亞型特異性抗體
品名 | 貨號 | 宿主 | 應(yīng)用 |
Anti-AKT3 | A18-63R | Rabbit | WB |
Anti-AMPK alpha 1 | P47-63R | Rabbit | WB |
Anti-CAMK1 | C07-60M | Mouse, IgG1, 5H8 | WB |
Anti-CHK2 | C48-60M | Mouse, IgG1, 7F9 | WB |
Anti-ERK1 | M29-60M | Mouse, IgG1, E32 | WB, IP |
Anti-ERK1 | M29-60BM | Mouse, IgG1, E19 | WB, IP |
Anti-GSK3 alpha | G08-63R | Rabbit | WB |
Anti-GSK3 beta | G09-60M | Mouse, IgG1, 6C2 | WB |
Anti-HSP90 beta | H36-63R | Rabbit | WB |
2、偶聯(lián)修飾的抗體
品名 | 貨號 | 宿主 | 應(yīng)用 |
Anti-5-Methylated Cytosine (5-methyl cytosine) | C92-67S | Sheep, IgG | WB, IP |
Anti-Acetylated Lysine | L95-66R | Rabbit | WB, ELISA, PI, IHC, IF |
Anti-Acetylated Lysine, Biotin Conjugated | L95-66BR | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Acetylated Lysine, FITC Conjugated | L95-66CR | Rabbit | For direct immunofluorescence assay |
Anti-Acetylated Lysine, HRP Conjugated | L95-66DR | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Methylated Arginine (NG, NG-Di-methyl) | A96-67R | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Methylated Arginine (NG-Mono-methyl) | A95-67R | Rabbit | WB, ELISA, IF, IHC, IP |
Anti-Methylated Lysine (Tri- epsilon-N-methyl) | L95-67R | Rabbit | WB, ELISA, IF, IHC, IP |
3、磷酸化特異性抗體
該產(chǎn)品系列共包括82款磷酸化特異性抗體，下表僅列部分產(chǎn)品，
品名 | 貨號 | 宿主 | 應(yīng)用 |
Anti-phospho-14-3-3 beta (Ser58) | Y71-365R | Rabbit, IgG | WB, IHC |
Anti-phospho-4EBP1 (Thr45) | E35-365R | Rabbit, IgG | WB, IHC |
Anti-phospho-AKT1/2/3 (Ser473) | A16-65BR | Rabbit, IgG | WB, IHC |
Anti-phospho-AKT1/2/3 (Thr308) | A16-65R | Rabbit, IgG | WB, IHC |
Anti-phospho-ASK1 (Ser966) | M13-65R | Rabbit, IgG | IHC |
Anti-phospho-ATF2 (Ser112) | A10-565R | Rabbit, IgG | IHC |
Anti-phospho-ATF2 (Ser490 Ser498) | A10-565BR | Rabbit, IgG | WB, IHC |
Anti-phospho-BRCA1 (Ser1423) | B87-365R | Rabbit, IgG | IHC |
Anti-phospho-c-KIT (Tyr721) | K06-65R | Rabbit, IgG | WB |
Anti-phospho-c-KIT (Tyr936) | K06-65BR | Rabbit, IgG | IHC |
4、Primary Antibodies
該產(chǎn)品系列共包括279款原初抗體，下表僅列部分產(chǎn)品
品名 | 貨號 | 宿主 | 應(yīng)用 |
Anti-4EBP1 | E35-563R | Rabbit, IgG | WB, ELISA, ICC |
Anti-ADD1 | A38-63R | Rabbit | WB |
Anti-AFX | A42-63R | Rabbit | WB |
Anti-AKT (pan) | A16-63R | Rabbit | WB |
Anti-AKT (pan) | A16-63BR | Rabbit | WB |
Anti-AKT1 | A16-60M | Mouse, Monoclonal, 9A4 | WB |
Anti-AKT1 | A16-63CR | Rabbit, IgG | WB, ELISA, IF, IHC |
Anti-AKT2/3 | A17-63BR | Rabbit | WB |
Anti-ALK2 | A06-63R | Rabbit, IgG | WB, ELISA |
Anti-ALK4 | A07-63R | Rabbit, IgG | WB, ELISA |
5、二抗
品名 | 貨號 | 宿主 | 應(yīng)用 |
Anti-Mouse HRP | G32-62G | Goat Polyclonal | WB, ELISA |
Anti-Rabbit HRP | G33-62G | Goat Polyclonal | WB, ELISA |
6、Tag標(biāo)簽抗體
品名 | 貨號 | 宿主 | 應(yīng)用 |
Anti-DYKDDDDK | F51-61M | Mouse, IgG2b, FG4R | WB, ELISA, IP, IS |
Anti-DYKDDDDK | F51-63R | Rabbit | WB |
Anti-GFP | G46-60M | Mouse, IgG1, GF28R | WB |
Anti-GST | G52-61M | Mouse, IgG2a, G2R | WB |
Anti-HA | H98-61M | Mouse, IgG3, C10 | WB, ELISA, IP, IS |
Anti-HA | H98-63R | Rabbit Polyclonal | WB, ELISA, IP, IS |
Anti-His | H99-61M | Mouse, IgG2b, EH158 | WB, ELISA, IP, IS |
Anti-His | H99-63R | Rabbit | WB, ELISA, IP, IS |
Anti-Myc | M86-61M | Mouse, IgG1, M19 | WB, ELISA, IP, IS |
Anti-RFP | R46-61M | Mouse, IgG1, RF5R | WB |
Anti-V5 | V05-61M | Mouse, IgG1, V4RR | WB, ELISA, IP, IS |
三、生物制劑產(chǎn)品系列
1、表觀遺傳酶激活劑
品名 | 貨號 | CAS 注冊號 | 分子式 | 純度 |
BML-278 | S35-904C | N/F | C24H25NO4 | >98% (TLC) |
CTPB | P07-903 | 586976-24-1 | C31H43ClF3NO2 | 98% |
Resveratrol | S35-904 | 501-36-0 | C14H12O3 | >98% |
SirtAct | S35-904E | 839699-72-8 | C20H25N5O2 | 98% (TLC) |
2、表觀遺傳酶抑制劑
該產(chǎn)品系列共包括33款表觀遺傳研究酶類的抑制劑，下表僅列部分產(chǎn)品
品名 | 貨號 | 應(yīng)用 |
2’-Deoxy-5-fluorocytidine | D353-904D | 不可逆DNA甲基轉(zhuǎn)移酶抑制劑 |
5-Azacytidine | D353-904 | DNA低甲基化試劑 |
AK-7 | S36-904 | SIRT2抑制劑 |
APICIDIN | H83-904B | HDAC抑制劑 |
BIX-01294 3HCl | S344-903 | Histone甲基轉(zhuǎn)移酶抑制劑 |
BML-210 | H83-904C | HDAC抑制劑 |
C-646 | K311-903 | HAT抑制劑 |
Chaetocin | K421-904C | Ly甲基轉(zhuǎn)移酶抑制劑 |
CPTH2 | K311-903B | HAT 抑制劑 |
3、激酶激活劑
品名 | 貨號 | CAS 注冊號 | 分子式 | 純度 |
8-pCPT-2-O-Me-cAMP-AM | R46-905 | 1152197-23-3 | C20H21ClN5O8PS | >97% (HPLC) |
AICAR | P47-900B | 2627-69-2 | C9H14N4O5 | >99% (TLC); NMR (Conforms) |
4、激酶抑制劑
該產(chǎn)品系列共包括80款常用激酶抑制劑，下表僅列部分產(chǎn)品
品名 | 貨號 | 應(yīng)用 |
6BIO | G08-900 | GSK3 inhibitor |
A83-01 | A09-900 | ALK inhibitor |
AAL-993 | F11-900C | VEGF inhibitor |
AG-1296 | P12-900 | PDGFR Inhibitor |
AG-1478 | E10-900B | EGFR inhibitor |
AG-1517 | K11-900B | Tyrosine kinase inhibitor |
5、磷酸酶抑制劑
品名 | 貨號 | CAS 注冊號 | 分子式 | 純度 |
Cantharidin | P16-902C | 56-25-7 | C10H12O4 | >98% (HPLC) |
EX-527 | S35-904F | 49843-98-3 | C13H13ClN2O | 98% (TLC) |
NSC-663284 | C04-902 | 383907-43-5 | C15H16ClN3O3 | >98% |
Okadaic acid, free acid | P16-902 | 78111-17-8 | C44H68O13 | >98% (TLC) |
6、內(nèi)參siRNA
品名 | 貨號 |
beta-Actin Positive Control siRNA | A03-911D |
Cy3 Labeled Negative Control siRNA | S02-910N |
FAM Labeled Negative Control siRNA | S03-910N |
GAPDH Positive Control siRNA | G13-911B |
Unlabeled Negative Control siRNA | S01-910N |
7、激酶研究常用siRNA
該產(chǎn)品系列共包括782款常用激酶的siRNA，下表僅列部分產(chǎn)品
品名 | 貨號 |
14-3-3 alpha/beta siRNA Set I | Y71-911 |
14-3-3 epsilon siRNA Set I | Y75-911 |
14-3-3 sigma siRNA Set I | Y86-911 |
14-3-3 theta siRNA Set I | Y84-911 |
14-3-3 zeta siRNA Set I | Y92-911 |
4EBP1 siRNA Set I | E35-911 |
AATK siRNA Set I | A02-911 |
ABL1 siRNA Set I | A03-911 |
ABL2 siRNA Set I | A04-911 |
ACK siRNA Set I | A05-911 |
ACVR2A siRNA Seti | A35-911 |
四、信號通路蛋白及酶
該產(chǎn)品系列包括目前常用的信號通路蛋白及相關(guān)酶類，品種多種多樣，包括：乙酰/甲基轉(zhuǎn)移酶系列、適配蛋白系列、凋亡通路系列、精氨酸脫亞氨酶系列、細(xì)胞周期蛋白系列、細(xì)胞應(yīng)激及分子伴侶蛋白系列、去乙酰化/甲基化酶系列、二氫嘧啶酶系列、雙加氧酶系列、果糖激酶系列、G-蛋白家族產(chǎn)品系列、激酶突變體產(chǎn)品系列、蛋白激酶產(chǎn)品系列、脂質(zhì)氧化酶系列、微管/肌動蛋白相關(guān)蛋白產(chǎn)品系列、磷脂酶C家族產(chǎn)品系列、超氧化物歧化酶產(chǎn)品系列、Tau蛋白及其相關(guān)產(chǎn)品系列、轉(zhuǎn)錄因子產(chǎn)品系列、泛素蛋白產(chǎn)品系列以及無活性激酶產(chǎn)品系列。
五、信號通路相關(guān)檢測試劑
該產(chǎn)品系列包括檢測試劑、脂類酶底物、寡氨酸底物、肽底物、蛋白酶底物等產(chǎn)品系列。
六、胞外配體蛋白
該產(chǎn)品系列包括細(xì)胞趨化因子、細(xì)胞因子及生長因子（生長因子共134種，下表僅列部分）。
品名 | 貨號 | 應(yīng)用 |
IP-10 | I838-40N | Cell Assay |
RANTES (CCL5) | R801-40N | Cell Assay |
SDF-1 | S821-40N | Cell Assay |
IFN-gamma | I837-40N |
|
TNF-alpha | T860-40N |
|
TNF-beta | T861-40BG |
|
TNFB | T861-40N |
|
TRAIL | T880-40N |
|
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